CD18 antibodies- functional grade, mouse

CD18 antibodies- functional grade, mouse

Clone: M18/2
Clone M18/2 recognizes the CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.


The mouse CD18 pure – functional grade antibody is suited for functional assays, for example,
in vitro
in vivo
stimulation of cell-adhesion and blocking of metastasis.

Alternative names

Integrin beta-2 (ITGB2), LTbetaR, Ltar, TNF-R-III, LTBR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, TNFCR

Technical specifications

  • Antigen: CD18
  • Clone: M18/2
  • Isotype: rat IgG2aκ
  • Alternative names of antigen: Integrin beta-2 (ITGB2), LTbetaR, Ltar, TNF-R-III, LTBR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, TNFCR
  • Entrez Gene ID: 17000
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: T cells, NK cells
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578
    2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
    3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501
Product options: 1

CD18 pure - functional grade, mouse

500 µg in 0.5 mL
EUR 322,00