CD178 antibodies, human

CD178 antibodies, human

Clone: NOK-1 | Dilution: 1:50
Clone NOK-1 reacts with CD178, a type II transmembrane glycoprotein, also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.

Alternative names

FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Technical specifications

  • Antigen: CD178
  • Clone: NOK-1
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6
  • Entrez Gene ID: 356
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells, granulocytes, lymphocytes, monocytes, neutrophils, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Kayagaki, N. et al. (1995) Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182: 1777-1783
    2. Suda, T. et al. (1993) Molecular cloning and expression of human Fas ligand. Cell 75: 1169-1178
    3. Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10: 1215-1225
Product options: 2
130-118-491

CD178-PE, human

for 30
tests
(1)
EUR 110,00 
130-118-353

CD178-PE, human

for 100
tests
(1)
EUR 265,00