CD170 (Siglec-5) antibodies, human

CD170 (Siglec-5) antibodies, human

Clone: REA1077 | Dilution: 1:50
Clone REA1077 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds α 2-3- and α 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.
Additional information: Clone REA1077 displays negligible binding to Fc receptors.

Alternative Names

CD33L2, OB-BP2, OBBP2, Siglec-5

Technical specifications

  • Antigen: CD170 (Siglec-5)
  • Clone: REA1077
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD33L2, OB-BP2, OBBP2, Siglec-5
  • Entrez Gene ID: 8778
  • Molecular mass of antigen [kDa]: 59
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    bonobo (
    Pan paniscus
    )
  • Distribution of antigen: dendritic cells, macrophages, monocytes, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
Product options: 14

Product information

Size
Order no.
Price

CD170 (Siglec-5)-FITC, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-194
EUR 86,00 

CD170 (Siglec-5)-FITC, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-017
EUR 60,00 

CD170 (Siglec-5)-PE, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-195
EUR 112,00 

CD170 (Siglec-5)-PE, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-018
EUR 78,00 

CD170 (Siglec-5)-APC, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-196
EUR 146,00 

CD170 (Siglec-5)-APC, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-019
EUR 102,00 

CD170 (Siglec-5)-PE-Vio615, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-197
EUR 146,00 

CD170 (Siglec-5)-PE-Vio615, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-020
EUR 102,00 

CD170 (Siglec-5)-PE-Vio770, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-198
EUR 146,00 

CD170 (Siglec-5)-PE-Vio770, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-021
EUR 102,00 

CD170 (Siglec-5)-VioBright 515, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-200
EUR 201,00 

CD170 (Siglec-5)-VioBright 515, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-023
EUR 375,00 

CD170 (Siglec-5)-Biotin, human

  • REA1077
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-201
EUR 86,00 

CD170 (Siglec-5)-Biotin, human

  • REA1077
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-024
EUR 60,00 

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