CD166 antibodies, human

Clone: REA442 | Dilution: 1:11
Clone REA442 recognizes the human CD166 antigen, a single-pass type I membrane protein also known as activated leukocyte cell adhesion molecule (ALCAM). CD166, a member of the immunoglobulin superfamily and a ligand for the lymphocyte antigen CD6, mediates homophilic and heterophilic adhesion. It is expressed on activated leukocytes T cells, B cells, monocytes, hematopoietic stem cells (HSCs), metastasizing melanoma, neuronal cells, endothelial cells, hematopoiesis-supporting osteoblastic cell lines, and mesenchymal stem cells (MSCs). CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human HSCs and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
Additional information: Clone REA442 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD166
  • Clone: REA442
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ALCAM, MEMD
  • Entrez Gene ID: 214
  • Molecular mass of antigen [kDa]: 62
  • Distribution of antigen: hematopoietic stem cells, T cells, B cells, monocytes, melanoma, endothelial cells, mesenchymal stem cells, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, Biotin, VioBright FITC
  • Selected references

    1. Chitteti, B. R. et al. (2014) CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood 124(4): 519-529
    2. Degen, W. G. et al. (1998) MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). Am. J. Pathol. 152(3): 805-813
    3. Ni, C. et al. (2013) Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis. PLoS One 8(8): e70958
Product options: 4
for 30
EUR 124,00 
for 100
EUR 299,00 
for 30
EUR 93,00 
for 100
EUR 227,00 

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