CD158e1/e2 antibodies, human

CD158e1/e2 antibodies, human

Clone: REA168 | Dilution: 1:11
Clone REA168 recognizes the CD158e1/e2 antigens, which are single-pass type I membrane proteins. CD158e is expressed on CD56
dim
CD16
+
natural killer (NK) cells and CD8
+
T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long or short cytoplasmic domain. According to the length of their cytoplasmic tail, KIRs can be further subdivided into inhibitory KIRs and activating KIRs. The CD158e1 antigen is also known as KIR3DL1 (KIR, three Ig like domain extracellular domains, long cytoplasmic tail, 1) and the CD158e2 antigen as KIR3DS1 (KIR, three extracellular Ig like domains, short cytoplasmic tail, 1). Within the KIR3DL1/S1 gene locus, CD158e2 represents a conserved allelic variant and displays unique features in comparison to the highly polymorphic CD158e1 allele. CD158e1 provides an inhibitory signal of NK cell lytic activity upon interaction with its specific ligand, HLA-Bw4. Despite the lack of formal evidence for an interaction of CD158e2 with HLA-Bw4 or any other HLA class I subtype, a growing number of associations between the presence of CD158e2 and the outcome of viral infections have been described. Especially, the potential protective role of CD158e2 in combination with HLA-Bw4-I80 in the context of HIV-1 infection has been studied intensively.
Additional information: Clone REA168 displays negligible binding to Fc receptors.

Alternative Names

KIR3DL1, KIR3DS1, HLA-BW4-specific inhibitory NK cell receptor, MHC class I NK cell receptor, Natural killer-associated transcript 3 (NKAT-3, NKAT3), p70 natural killer cell receptor clones CL-2/CL-11 (p70 NK receptor CL-2/CL-11), KIRp70/NKB1

Technical specifications

  • Antigen: CD158e1/e2
  • Clone: REA168
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KIR3DL1, KIR3DS1, HLA-BW4-specific inhibitory NK cell receptor, MHC class I NK cell receptor, Natural killer-associated transcript 3 (NKAT-3, NKAT3), p70 natural killer cell receptor clones CL-2/CL-11 (p70 NK receptor CL-2/CL-11), KIRp70/NKB1
  • Entrez Gene ID: 3811, 3813
  • Molecular mass of antigen [kDa]: 44
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
Product options: 16

Product information

Size
Order no.
Price

CD158e1/e2-FITC, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-882
EUR 65,00 

CD158e1/e2-FITC, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-836
EUR 255,00 

CD158e1/e2-PE, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-533
EUR 91,00 

CD158e1/e2-PE, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-484
EUR 236,00 

CD158e1/e2-APC, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-534
EUR 113,00 

CD158e1/e2-APC, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-485
EUR 255,00 

CD158e1/e2-VioBlue, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-110-453
EUR 112,00 

CD158e1/e2-VioBlue, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-110-447
EUR 296,00 

CD158e1/e2-PE-Vio770, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-535
EUR 113,00 

CD158e1/e2-PE-Vio770, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-486
EUR 278,00 

CD158e1/e2-APC-Vio770, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-884
EUR 98,00 

CD158e1/e2-APC-Vio770, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-838
EUR 313,00 

CD158e1/e2-PerCP-Vio700, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-883
EUR 98,00 

CD158e1/e2-PerCP-Vio700, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-837
EUR 313,00 

CD158e1/e2-Biotin, human

  • REA168
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-532
EUR 74,00 

CD158e1/e2-Biotin, human

  • REA168
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-483
EUR 236,00 

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