CD152  antibodies – functional grade, mouse

CD152 antibodies – functional grade, mouse

Clone: UC10-4B9
The monoclonal antibody UC10-4B9 reacts with CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a costimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative names

CTLA4, CTLA-4, Ly-56

Technical specifications

  • Antigen: CD152
  • Clone: UC10-4B9
  • Isotype: hamster IgG1
  • Alternative names of antigen: CTLA4, CTLA-4, Ly-56
  • Entrez Gene ID: 12477
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: B cells, lymphocytes, T cells
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5): 405-413
    2. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
    3. June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15(7): 321-331
Product options: 1
130-097-503

CD152 pure - functional grade, mouse

500 µg in 0.5 mL
EUR 325,00