CD132 antibodies, human

CD132 antibodies, human

Clone: REA313 | Dilution: 1:50
Clone REA313 recognizes the human CD132 antigen, a 65–70 kDa single-pass type I membrane protein also known as common γ chain, which is shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. CD132 is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. The most common form of severe combined immune deficiency in humans, with lack of circulating T cells, a normal or increased number of B lymphocytes, and an X-linked pattern of inheritance (XSCID) has been shown to be due to defects of the CD132 gene.
Additional information: Clone REA313 displays negligible binding to Fc receptors.

Alternative names

IL2RG, CIDX, IL-2RG, IMD4, p64, SCIDX, SCIDX1

Technical specifications

  • Antigen: CD132
  • Clone: REA313
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL2RG, CIDX, IL-2RG, IMD4, p64, SCIDX, SCIDX1
  • Entrez Gene ID: 3561
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: T cells, B cells, lymphocytes, NK cells, monocytes, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Ramsey, C. et al. (2008) The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J. Immunol. 180(8): 5320-5326
    2. Russell, S. M. et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 262(5141): 1880-1883
    3. Takesita, T. et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science 257(5068): 379-382
Product options: 2
130-125-107

CD132-PE, human

for 30
tests
(1)
EUR 110,00 
130-125-088

CD132-PE, human

for 100
tests
(1)
EUR 265,00 

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