CD125 (IL-5Rα) antibodies, mouse

CD125 (IL-5Rα) antibodies, mouse

Clone: REA343 | Dilution: 1:50
Clone REA343 recognizes the mouse CD125 antigen, a single-pass type I membrane protein, also known as interleukin-5 receptor subunit α (IL-5Rα). The IL-5 receptor is a heterodimer composed of a ligand specific α subunit and a signal transducing β subunit which is shared by the receptors for IL-3, GM-CSF, and IL-5. CD125 is expressed on eosinophils, basophils, and B cells. IL-5 is a conserved hematopoietic cytokine which is mainly produced by Tʜ2 cells after stimulation with antigens, and by mast cells upon stimulation with an allergen/IgE complex or a calcium ionophore. The overexpression of IL-5
in vivo
significantly increases the numbers of eosinophils and B cells, while mice lacking the functional gene for IL-5 display various developmental and functional impairments in the B cell and eosinophil lineages.
Additional information: Clone REA343 displays negligible binding to Fc receptors.

Alternative names

CDw125, Il5r, IL-5RA

Technical specifications

  • Antigen: CD125 (IL-5Rα)
  • Clone: REA343
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CDw125, Il5r, IL-5RA
  • Entrez Gene ID: 16192
  • Molecular mass of antigen [kDa]: 45
  • Distribution of antigen: granulocytes, basophils, eosinophils, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615
  • Selected references

    1. Takaki, S. et al. (1990) Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 9(13): 4367-4374
    2. Mao, H. et al. (2006) Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing vector on bone marrow eosinophilopoiesis in asthmatic mice. Adv. Ther. 23(6): 938-956
    3. Kusano, S. et al. (2012) Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 21(6): 850-864
Product options: 3
30 µg in 200 µL (1)
EUR 82,00 
150 µg in 1 mL (1)
EUR 237,00 
30 µg in 200 µL (1)
EUR 103,00 

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