CD123 antibodies, mouse

CD123 antibodies, mouse

Clone: REA114 | Dilution: 1:10
Clone REA114 recognizes CD123, the alpha chain of the IL-3 receptor. CD123 is 60–70 kDa membrane glycoprotein and interacts in mice with common beta chain (betac) and beta IL-3 subunits to form functional heterodimeric IL-3 receptors. CD123 alone can bind IL-3 with low affinity, however a high affinity binding is displayed by the heterodimeric forms. Besides ligand binding, the alpha chain of IL-3R was also shown to be necessary for the activation of STAT-5. Expression of CD123 is widely found in hematopoietic cells and in addition on basophils, mast cells, and megakaryocytes. AKR, RF, A/J, and NZB mouse strains carry a 5-bp deletion in the IL-3Ra gene and thus lack the expression of CD123.
Additional information: Clone REA114 displays negligible binding to Fc receptors.

Alternative names

IL3RA, CDw123, SUT-1

Technical specifications

  • Antigen: CD123
  • Clone: REA114
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IL3RA, CDw123, SUT-1
  • Entrez Gene ID: 16188
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: B cells, basophils, bone marrow, brain, endothelial cells, eosinophils, granulocytes, leukemia cells, macrophages, mast cells, megakaryocytes, monocytes, myeloid cells, placenta, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Hara, T. et al. (1995) Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85: 2331-2336
    2. Reddy, E. P. et al. (2000) IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene 19(21): 2532-2547
    3. Lehmann, C. et al. (2014) Longitudinal analysis of distribution and function of plasmacytoid dendritic cells in peripheral blood and gut mucosa of HIV infected patients. J. Infect. Dis. 209: 940-949
Product options: 8
130-102-869

CD123-PE, mouse

9 µg in 300 µL (1)
EUR 27,00 
130-102-583

CD123-PE, mouse

30 µg in 1 mL (1)
EUR 80,00 
130-102-868

CD123-APC, mouse

9 µg in 300 µL (1)
EUR 44,00 
130-102-531

CD123-APC, mouse

30 µg in 1 mL (1)
EUR 80,00 
9 µg in 300 µL (1)
EUR 44,00 
30 µg in 1 mL (1)
EUR 100,00 
9 µg in 300 µL (1)
EUR 15,00 
30 µg in 1 mL (1)
EUR 40,00 

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