CD120b (TNF-RII) antibodies, mouse

CD120b (TNF-RII) antibodies, mouse

Clone: REA228 | Dilution: 1:10
Clone REA228 recognizes the extracellular part of the membrane-bound and truncated soluble form of the mouse CD120b antigen, a 75 kD type I transmembrane protein, which is also known as Tumor Necrosis Factor Receptor Type II (TNF-RII). CD120b is a receptor with high affinity for the mouse cytokine TNF-α and with lower affinity for LT-α. It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA228 displays negligible binding to Fc receptors.

Alternative Names

TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor

Technical specifications

  • Antigen: CD120b (TNF-RII)
  • Clone: REA228
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor
  • Entrez Gene ID: 21938
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: B cells, T cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected References

    1. van Mierlo, G. J. et al. (2008) Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators J. Immunol. 180(5): 2747-2751
    2. Lewis, M. et al. (1991) Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific Proc. Natl. Acad. Sci. U.S.A. 88(7): 2830-2834
    3. Al-Lamki, R. S. et al. (2013)
      TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit
      +
      cardiac stem cells in ischemic heart disease.
      Stem Cells 31(9): 1881-1892
    4. Siegmund, D. et al. (2016) Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis 7(9): e2375
Product options: 12

Product information

Size
Order no.
Price

CD120b (TNF-RII)-PE, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-744
EUR 27,00 

CD120b (TNF-RII)-PE, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-697
EUR 54,00 

CD120b (TNF-RII)-APC, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-745
EUR 44,00 

CD120b (TNF-RII)-APC, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-698
EUR 86,00 

CD120b (TNF-RII)-PE-Vio770, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-746
EUR 44,00 

CD120b (TNF-RII)-PE-Vio770, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-699
EUR 86,00 

CD120b (TNF-RII)-APC-Vio770, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-747
EUR 54,00 

CD120b (TNF-RII)-APC-Vio770, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-700
EUR 108,00 

CD120b (TNF-RII)-PerCP-Vio700, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-748
EUR 54,00 

CD120b (TNF-RII)-PerCP-Vio700, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-701
EUR 108,00 

CD120b (TNF-RII)-Biotin, mouse

  • REA228
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-104-743
EUR 15,00 

CD120b (TNF-RII)-Biotin, mouse

  • REA228
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-104-696
EUR 32,00