CD11a/CD18 antibodies, mouse

CD11a/CD18 antibodies, mouse

Clone: REA880 | Dilution: 1:50
Clone REA 880 recognizes the CD11a/CD18 heterodimer, also known as lymphocyte function–associated antigen 1 (LFA-1). LFA-1 is a member of the integrin family and consists of two chains, a (CD11a) and b2 (CD18). It is expressed on T and B cells as well as on macrophages and neutrophils. LFA-1 plays an essential role in the immune system, e.g., in leukocyte adhesion by interaction with ICAM-1 and ICAM-2, in cytotoxic T cell–mediated killing, antibody-dependent killing by granulocytes and monocytes, and in T cell proliferation.
Additional information: Clone REA880 displays negligible binding to Fc receptors.

Alternative Names

LFA-1

Technical specifications

  • Antigen: CD11a/CD18
  • Clone: REA880
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LFA-1
  • Entrez Gene ID: 16408, 16414
  • Molecular mass of antigen [kDa]: 209
  • Distribution of antigen: T cells, B cells, macrophages, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Kaufmann, Y. et al. (1991) Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells. J. Immunol. 147(1): 369-374
    2. Lub, M. et al. (1995) Ins and outs of LFA-1. Immunol. Today 16(10): 479-483
    3. Liu, Z. et al. (2006) Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood 107(3): 1063-1069
    4. Liu, Y. et al. (2011) Expression of p16INK4a prevents cancer and promotes aging in lymphocytes. Blood 117: 3257-3267
Product options: 8
130-114-422

CD11a/CD18-FITC, mouse

30 µg in 200 µL (1)
EUR 40,00 
130-114-423

CD11a/CD18-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-114-316

CD11a/CD18-PE, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-114-424

CD11a/CD18-APC, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-114-317

CD11a/CD18-APC, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-114-425

CD11a/CD18-PE-Vio770, mouse

30 µg in 200 µL (1)
EUR 100,00 
130-114-421

CD11a/CD18-Biotin, mouse

30 µg in 200 µL (1)
EUR 40,00 
130-114-314

CD11a/CD18-Biotin, mouse

150 µg in 1 mL (1)
EUR 120,00