CD112 antibodies, human

CD112 antibodies, human

Clone: R2.525 | Dilution: 1:11
Clone R2.525 recognizes the human CD112 antigen, a single-pass type I membrane protein, which is also known as nectin-2, herpesvirus entry mediator B (HveB), or poliovirus receptor-related protein 2 (PRR2). Nectins are Ca
2+
-independent cell adhesion molecules that consist of 4 members: CD111 (Nectin-1), CD112 (Nectin-2), CD113 (Nectin-3), and Nectin-4. CD112 is one of the plasma membrane components of adherens junctions and is widely expressed in human tissues, including hematopoietic cells. It is also over-expressed in various cancers, e.g. breast and ovarian cancers. It has been reported to regulate cell adhesion between epithelial cells through the formation of trans-dimers between adjacent cells. CD112-mediated cell adhesion induces the formation of E-cadherin-based adherens junctions followed by the formation of claudin-based tight junctions. In addition to its function as a cell adhesion molecule, previous studies have suggested that CD112 acts as an organizer of Sertoli cell–spermatid junctions in the testis and of synapse formation by neurons and as an entry receptor for viruses. CD112 is also known to be one of the ligands of CD226 (DNAM-1) and TIGIT.

Alternative Names

PVRL2, HveB, PRR2, PVRR2, Nectin-2

Technical specifications

  • Antigen: CD112
  • Clone: R2.525
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: PVRL2, HveB, PRR2, PVRR2, Nectin-2
  • Entrez Gene ID: 5819
  • Molecular mass of antigen [kDa]: 55
  • Distribution of antigen: endothelial cells, leukocytes, epithelial cells, testicle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin
Product options: 4

Product information

Size
Order no.
Price

CD112-PE, human

  • R2.525
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-056
EUR 110,00 

CD112-PE, human

  • R2.525
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-001
EUR 292,00 

CD112-Biotin, human

  • R2.525
  • 1:11
  • For research use only
for 30
tests
(1)
130-109-055
EUR 85,00 

CD112-Biotin, human

  • R2.525
  • 1:11
  • For research use only
for 100
tests
(1)
130-109-000
EUR 248,00 

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