CD111 antibodies, human

CD111 antibodies, human

Clone: REA1210 | Dilution: 1:50
Clone REA1210 recognizes the human CD111 antigen, a 75 kDa type I transmembrane glycoprotein also known as poliovirus receptor related 1 protein (PRR1), PVRL1, HveC, and Nectin-1. Nectins are involved in the formation of the mechanical adhesive puncta adherentia junctions of synapses. CD111 is an adhesion molecule that can be found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. In the chemical synapse, CD111 interacts with PVRL3 and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains. CD111 also functions as an entry receptor for herpes simplex virus and pseudorabies virus.
Additional information: Clone REA1210 displays negligible binding to Fc receptors.

Alternative names

PVRL1, CLPED1, ED4, HV1S, HveC, OFC7, PRR, PVRR, Nectin-1, NECTIN1

Technical specifications

  • Antigen: CD111
  • Clone: REA1210
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PVRL1, CLPED1, ED4, HV1S, HveC, OFC7, PRR, PVRR, Nectin-1, NECTIN1
  • Entrez Gene ID: 5818
  • Molecular mass of antigen [kDa]: 54
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, VioBright 515
  • Selected references

    1. Cocchi, F. et al. (1998) The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D. Proc. Natl. Acad. Sci. U.S.A. 95(26): 15700-15705
    2. Rikitake, Y. et al. (2012) The role of nectins in different types of cell-cell adhesion. J. Cell. Sci. 125: 3713-3722
    3. Takahashi, K. et al. (1999) Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J. Cell Biol. 145(3): 539-549
Product options: 8
130-123-223

CD111-PE, human

for 30
tests
(1)
EUR 110,00 
130-123-216

CD111-PE, human

for 100
tests
(1)
EUR 265,00 
130-123-224

CD111-APC, human

for 30
tests
(1)
EUR 110,00 
130-123-217

CD111-APC, human

for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 150,00 
for 100
tests
(1)
EUR 360,00