CD110 antibodies, human

CD110 antibodies, human

Clone: REA250 | Dilution: 1:11
Clone REA250 recognizes the CD110 antigen, a type I transmembrane protein and a member of the hematopoietin receptor family, which is also known as myeloproliferative leukemia protein (MPL) or thrombopoietin receptor (TPO-R). CD110 is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets. It serves as a receptor for thrombopoietin and CD110 deficiency leads to severe thrombocytopenia, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Additional information: Clone REA250 displays negligible binding to Fc receptors.

Alternative Names

MPL, C-MPL, MPLV, THCYT2, TPOR

Technical specifications

  • Antigen: CD110
  • Clone: REA250
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MPL, C-MPL, MPLV, THCYT2, TPOR
  • Distribution of antigen: platelets, megakaryocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Vigon, I. et al. (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 89: 5640-5644
    2. Chou, F. S. et al. (2011) The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. J. Cell. Biochem. 112(6): 1491-1498
    3. Kaushansky, K. et al. (1998) The role of the MPL receptor in myeloproliferative disorders. Leukemia 12: S47-S50
Product options: 8
130-101-648

CD110-PE, human

for 30
tests
(1)
EUR 110,00 
130-101-743

CD110-PE, human

for 100
tests
(1)
EUR 265,00 
130-101-647

CD110-APC, human

for 30
tests
(1)
EUR 110,00 
130-101-644

CD110-APC, human

for 100
tests
(1)
EUR 265,00 
130-101-649

CD110-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-101-744

CD110-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-111-660

CD110-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-111-581

CD110-Biotin, human

for 100
tests
(1)
EUR 220,00