CD106 (VCAM-1) antibodies, human

CD106 (VCAM-1) antibodies, human

Clone: REA269 | Dilution: 1:50
Clone REA269 recognizes the CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1) or INCAM-100. CD106 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
Additional information: Clone REA269 displays negligible binding to Fc receptors.

Alternative names

VCAM1, INCAM-100

Technical specifications

  • Antigen: CD106 (VCAM-1)
  • Clone: REA269
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: VCAM1, INCAM-100
  • Entrez Gene ID: 7412
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: endothelial cells, dendritic cells, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Osborn, L. et al. (1992) Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1. J. Exp. Med. 176(1): 99-107
    2. Johnson, L. A. et al. (2008) Cell traffic and the lymphatic endothelium. Ann. N. Y. Acad. Sci. 1131: 119-133
    3. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
Product options: 2
130-122-008

CD106 (VCAM-1)-PE, human

for 30
tests
(1)
EUR 110,00 
130-121-992

CD106 (VCAM-1)-PE, human

for 100
tests
(1)
EUR 265,00