Anti-TrkA antibodies, human

Anti-TrkA antibodies, human

Clone: REA430 | Dilution: 1:50
Clone REA430 recognizes the human TrkA antigen, a single-pass type I membrane protein which is also known as neurotrophic tyrosine kinase receptor type 1 (NTRK1). TrkA is a member of the neurotrophic tyrosine kinase receptor family and is involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation, and survival of sympathetic and nervous neurons. TrkA is the high affinity catalytic receptor for the nerve growth factor (NGF). As such, it mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. Although originally isolated from neural tissues, a growing body of evidence supports a role for TrkA in tumorigenesis in non-neural tumors, primarily carcinomas.
Additional information: Clone REA430 displays negligible binding to Fc receptors.

Alternative Names

NTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk

Technical specifications

  • Antigen: TrkA
  • Clone: REA430
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk
  • Entrez Gene ID: 4914
  • Molecular mass of antigen [kDa]: 84
  • Distribution of antigen: neurons, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected References

    1. Kiris, E. et al. (2014)
      TrkA
      in vivo
      function is negatively regulated by ubiquitination.
      J. Neurosci. 34(11): 4090-4098
    2. Shelton, D. L. et al. (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci. 15(1 Pt 2): 477-491
    3. Lagadec, C. et al. (2009) TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 28(18): 1960-1970
Product options: 2
130-117-817

Anti-TrkA-PE, human

for 30
tests
(1)
EUR 115,00 
130-117-705

Anti-TrkA-PE, human

for 100
tests
(1)
EUR 270,00