Anti-TIGIT antibodies, human

Anti-TIGIT antibodies, human

Clone: REA1004 | Dilution: 1:50
Clone REA1004 recognizes the human T cell immunoglobulin and ITIM domain (TIGIT) antigen, a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation.
Additional information: Clone REA1004 displays negligible binding to Fc receptors.

Alternative Names

VSIG9, Vstm3, WUCAM

Technical specifications

  • Antigen: TIGIT
  • Clone: REA1004
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: VSIG9, Vstm3, WUCAM
  • Entrez Gene ID: 201633
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: dendritic cells, NK cells, T cells, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
Product options: 12

Product information

Size
Order no.
Price

Anti-TIGIT-PE, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-934
EUR 85,00 

Anti-TIGIT-PE, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-814
EUR 276,00 

Anti-TIGIT-APC, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-935
EUR 111,00 

Anti-TIGIT-APC, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-815
EUR 300,00 

Anti-TIGIT-PE-Vio615, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-936
EUR 111,00 

Anti-TIGIT-PE-Vio615, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-816
EUR 300,00 

Anti-TIGIT-PE-Vio770, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-937
EUR 111,00 

Anti-TIGIT-PE-Vio770, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-817
EUR 300,00 

Anti-TIGIT-VioBright 515, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-938
EUR 152,00 

Anti-TIGIT-VioBright 515, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-818
EUR 375,00 

Anti-TIGIT-Biotin, human

  • REA1004
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-939
EUR 65,00 

Anti-TIGIT-Biotin, human

  • REA1004
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-819
EUR 234,00 

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