Anti-THEMIS antibodies, human

Anti-THEMIS antibodies, human

Clone: REA463 | Dilution: 1:10
Clone REA463 recognizes the human thymocyte-expressed molecule involved in selection (THEMIS) antigen, a 73 kDa signaling protein, that is also known as thymocyte selection pathway associated (TSEPA), signaling phosphoprotein specific for T cells (SPOT), or GRB2-associated protein (GASP). THEMIS is rapidly tyrosine-phosphorylated upon TCR ligation and is required for the differentiation of immature CD4/CD8 double positive thymocytes into mature CD4 or CD8 single positive thymocytes. It is expressed only in the T cell lineage and is first detected in CD4/CD8 double negative thymocytes, reaching maximum levels at the CD4/CD8 double positive stage. Following thymocyte selection, THEMIS expression is decreased in mature CD4 and CD8 single positive thymocytes and peripheral T cells. Themis
−/−
mice show impaired positive selection during thymocyte development and severe reduction of mature thymocytes and peripheral T cells.
Additional information: Clone REA463 displays negligible binding to Fc receptors.

Alternative Names

C6orf190, C6orf207, GASP, SPOT, TSEPA, THMS1, GRB2-associated protein

Technical specifications

  • Antigen: THEMIS
  • Clone: REA463
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: C6orf190, C6orf207, GASP, SPOT, TSEPA, THMS1, GRB2-associated protein
  • Entrez Gene ID: 387357
  • Molecular mass of antigen [kDa]: 74
  • Distribution of antigen: T cells, thymocytes, T helper cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
Product options: 4

Product information

Size
Order no.
Price

Anti-THEMIS-PE, human

  • REA463
  • 1:10
  • For research use only
for 30
tests
(1)
130-108-271
EUR 112,00 

Anti-THEMIS-PE, human

  • REA463
  • 1:10
  • For research use only
for 100
tests
(1)
130-108-244
EUR 296,00 

Anti-THEMIS-APC, human

  • REA463
  • 1:10
  • For research use only
for 30
tests
(1)
130-108-272
EUR 146,00 

Anti-THEMIS-APC, human

  • REA463
  • 1:10
  • For research use only
for 100
tests
(1)
130-108-245
EUR 322,00 

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