Anti-STAT6 pY641 antibodies, mouse

Anti-STAT6 pY641 antibodies, mouse

Clone: REA390 | Dilution: 1:10
Clone REA390 recognizes the mouse signal transducer and activator of transcription 6 (STAT6) antigen phosphorylated at tyrosine 641 (pY641). STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven members of the STAT family are predominantly activated by growth factors and cytokines. STAT6 expression is found in many tissues. It is activated by two cytokines, IL-4 and IL-13, and plays a predominant role in the immune system. Once these cytokines bind to their cognate receptors, the associated Janus kinases (JAKs) are activated and phosphorylate conserved tyrosine residues on the receptor. Once phosphorylated, STAT6 forms homodimers and translocates to the nucleus. In the nucleus, STAT6 has the ability to bind directly to DNA via a DNA-binding domain and is able to regulate transcription. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis.
Additional information: Clone REA390 displays negligible binding to Fc receptors.

Alternative names

Signal transducer and transcription activator 6, IL-4 Stat

Technical specifications

  • Antigen: STAT6 pY641
  • Clone: REA390
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Signal transducer and transcription activator 6, IL-4 Stat
  • Entrez Gene ID: 20852
  • Molecular mass of antigen [kDa]: 93
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Hou, J. et al. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science 265(5179): 1701-1706
    2. Quelle, F. W. et al. (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15(6): 3336-3343
    3. Wick, K. R. et al. (2000) IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes. Mol. Immunol. 37(11): 641-652
Product options: 4
9 µg in 300 µL (1)
EUR 31,00 
30 µg in 1 mL (1)
EUR 82,00 
9 µg in 300 µL (1)
EUR 45,00 
30 µg in 1 mL (1)
EUR 82,00 

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