Anti-ROR1 antibodies, human

Anti-ROR1 antibodies, human

Clone: REA1051 | Dilution: 1:50
Clone REA1051 recognizes the human ROR1 antigen, also known as receptor tyrosine kinase-like orphan receptor 1. ROR1 has characteristics of an oncofetal gene and was recently identified to be overexpressed at the gene and protein levels in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). ROR1 expression has also been detected in ovarian cancer, renal cancer, melanoma, and lung adenocarcinoma, suggesting a general role of ROR1 in cancer genesis and/or maintenance. Moreover, ROR1 expression has been found in undifferentiated embryonic stem cells, in adipose tissue, at early stages of B cell development, but not in major adult tissues. Therefore, ROR1 is a potential therapeutic target and a biomarker to identify and enumerate malignant cells in CLL and MCL blood samples via flow cytometry.
Additional information: Clone REA1051 displays negligible binding to Fc receptors.

Alternative names

NTRKR1

Technical specifications

  • Antigen: ROR1
  • Clone: REA1051
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NTRKR1
  • Entrez Gene ID: 4919
  • Molecular mass of antigen [kDa]: 101
  • Distribution of antigen: tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Fukuda, T. et al. (2008) Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc. Natl. Acad. Sci. U.S.A. 105: 3047-3052
    2. Baskar, S. et al. (2008) Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 14(2): 396-404
    3. Hudecek, M. et al. (2010) The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood 116(22): 4532-4541
    4. Yang, J. et al. (2011) Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS One 6(6): e21018
    5. Daneshmanesh, A. H. et al. (2012) Monoclonal antibodies against ROR1 induce apoptosis of chronic lymphocytic leukemia (CLL) cells. Leukemia 26(6): 1348-1355
    6. Baskar, S. et al. (2012) Targeting malignant B cells with an immnunotoxin against ROR1. mAbs 4(3): 349-361
  • Customer reports and application notes

Product options: 8
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 150,00 
for 100
tests
(1)
EUR 360,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00