Anti-QA-1B antibodies, mouse

Anti-QA-1B antibodies, mouse

Clone: 6A8.6F10.1A6 | Dilution: 1:10
Clone 6A8.6F10.1A6 recognizes murine QA-1B, a 48 kDa non-classical MHC class Ib molecule encoded by the H2-T23 gene on chromosome 17. QA-1 associates with β2-microglobulin and its surface expression is found on activated hematopoietic cells, T cells, dendritic cells (DCs), macrophages, and neurons. Murine QA-1 presents a nine amino acid peptide called QA-1 determinant modifier (Qdm), peptides from proteins associated with infectious or inflammatory response, and a heat shock protein 60 (HSP60)–derived peptide (in the absence of Qdm) to immunoregulatory CD8
+
T cells. QA-1B also serves as a ligand for C-type lectin CD94/NKG2 receptors and depending on the NKG2 family member involved, this interaction can result in an inhibitory or an activating signal.

Alternative names

H2-T23

Technical specifications

  • Antigen: QA-1B
  • Clone: 6A8.6F10.1A6
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: H2-T23
  • Entrez Gene ID: 15040
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: T cells, hematopoietic stem cells, dendritic cells, macrophages, neurons
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, PE
  • Selected references

    1. Lu, L. et al. (2007)
      Regulation of activated CD4
      +
      T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.
      Immunity 26(5): 593-604
    2. Vance, R. E. et al. (1999) Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J. Exp. Med. 190: 1801-1812
    3. Lu, L. et al. (2006) The immunoregulatory effects of Qa-1. Immunol. Rev. 212: 51-59
Product options: 2
9 µg in 300 µL (1)
EUR 15,00 
30 µg in 1 mL (1)
EUR 40,00