Anti-PTEN antibodies, human and mouse

Anti-PTEN antibodies, human and mouse

Clone: REA270 | Dilution: 1:11
Clone REA270 recognizes the phosphatase and tensin homolog deleted on chromosome ten (PTEN) antigen, regardless of phosphorylation status. PTEN is a tumor suppressor gene which is also known as mutated in multiple advanced cancers 1 (MMAC1) or TGF-β–regulated and epithelial cell-enriched phosphatase (TEP-1). It has been found to be defective in a large number of human cancers like glioblastoma, breast, and prostate. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome. PTEN functions as a negative regulator of the phosphoinositide 3-kinase signaling pathway which has crucial roles in cell proliferation, survival, differentiation, and migration. The protein encoded by PTEN is a phosphatase that preferentially dephosphorylates phosphoinositide substrates.
Additional information: Clone REA270 displays negligible binding to Fc receptors.

Alternative names

BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1

Technical specifications

  • Antigen: PTEN
  • Clone: REA270
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
  • Entrez Gene ID: 5728
  • Molecular mass of antigen [kDa]: 47
  • Cross-reactivity: rat, dog
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Jing, L. et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275(5308): 1943-1947
    2. Lewis, C. et al. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. U.S.A. 96: 4240-4245
    3. Zhang, J. et al. (2006) PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441(7092): 518-522
Product options: 4
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 

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