Anti-PAX-5 (BSAP) antibodies, human and mouse

Anti-PAX-5 (BSAP) antibodies, human and mouse

Clone: REA140 | Dilution: 1:11
Clone REA140 recognizes PAX-5, which belongs to the paired box (PAX) gene family of transcription factors. PAX-5 is the only mammalian PAX transcription factor, which is expressed in hematopoietic cells. Within the hematopoietic cells, expression of PAX-5 is limited to cells of the B-lymphocyte lineage and it exerts transcriptional control of B cell commitment, development, and tumorigenesis. PAX-5 contains DNA binding conserved ‘paired’ domain, which consists of an N- and a C-terminal subdomain. Each subregion contains a homeodomain-like helix-turn-helix motif, which binds to a half-site of the PAX-5 recognition sequence. Depending upon the interaction partners, PAX-5 serves either as an activator or repressor of transcription. For instance, Groucho protein family members, by binding to a conserved octapeptide motif of PAX-5, enable PAX-5 to serve as a repressor.
Additional information: Clone REA140 displays negligible binding to Fc receptors.

Alternative Names

ALL3, BSAP, EBB-1, KLP

Technical specifications

  • Antigen: PAX-5 (BSAP)
  • Clone: REA140
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ALL3, BSAP, EBB-1, KLP
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected References

    1. He, T., et al. (2011) Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity. J. Biol. Chem. 286: 14137-14145
    2. Pridans, C. et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J. Immunol. 180: 1719-1728
    3. Fazio, G. et al. (2008) PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells. Cancer Res. 68: 181-189
Product options: 8
130-099-927

Anti-PAX-5 (BSAP)-PE, human and mouse

for 30
tests
(1)
EUR 110,00 
130-099-925

Anti-PAX-5 (BSAP)-PE, human and mouse

for 100
tests
(1)
EUR 265,00 
130-099-938

Anti-PAX-5 (BSAP)-APC, human and mouse

for 30
tests
(1)
EUR 110,00 
130-099-936

Anti-PAX-5 (BSAP)-APC, human and mouse

for 100
tests
(1)
EUR 265,00 
130-100-634

Anti-PAX-5 (BSAP)-PE-Vio770, human and mouse

for 30
tests
(1)
EUR 120,00 
130-100-678

Anti-PAX-5 (BSAP)-PE-Vio770, human and mouse

for 100
tests
(1)
EUR 290,00 
130-100-699

Anti-PAX-5 (BSAP)-PerCP-Vio700, human and mouse

for 30
tests
(1)
EUR 120,00 
130-100-640

Anti-PAX-5 (BSAP)-PerCP-Vio700, human and mouse

for 100
tests
(1)
EUR 290,00