Anti-p16 antibodies, human

Anti-p16 antibodies, human

Clone: REA973 | Dilution: 1:50
Clone REA973 recognizes the human p16 protein, a member of the cyclin-dependent kinases (CDKs), also known as cyclin-dependent kinase 4 inhibitor (CDKN2) or INK4A. p16 is a multiple tumor-suppressor protein that functions as a negative regulator of the proliferation of normal cells and tumorigenesis by forming heterodimers with CDK4 and CDK6. p16 is found in most of different cell types but it is not detected in brain or skeletal muscle.
Additional information: Clone REA973 displays negligible binding to Fc receptors

Alternative names

p16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l

Technical specifications

  • Antigen: p16
  • Clone: REA973
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: p16-INK4, p16-INK4A, ARF, MTS1, CDKN2, CDK4l
  • Entrez Gene ID: 1029
  • Molecular mass of antigen [kDa]: 17
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Serrano, M. et al. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366(6456): 704-707
    2. Okamoto, A. et al. (1994) Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 91(23): 11045-11049
    3. Bockstaele, L. et al. (2006) Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol. Cell. Biol. 26(13): 5070-5085
    4. Huang, X. et al. (2007) Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Biochem. Biophys. Res. Commun. 361(2): 287-293
Product options: 6
130-116-239

Anti-p16-FITC, human

for 30
tests
(1)
EUR 90,00 
130-116-136

Anti-p16-FITC, human

for 100
tests
(1)
EUR 220,00 
130-116-240

Anti-p16-PE, human

for 30
tests
(1)
EUR 110,00 
130-116-137

Anti-p16-PE, human

for 100
tests
(1)
EUR 265,00 
130-116-241

Anti-p16-APC, human

for 30
tests
(1)
EUR 110,00 
130-116-138

Anti-p16-APC, human

for 100
tests
(1)
EUR 265,00