Anti-Notch1 antibodies, human

Anti-Notch1 antibodies, human

Clone: REA849 | Dilution: 1:50
Clone REA849 recognizes the human neurogenic locus notch homolog protein 1 (Notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180–200 kDa disulfide-linked extracellular domain (Notch extracellular truncation (NEXT)), and a 120 kDa membrane-bound intracellular portion (Notch intracellular domain (NICD)). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, Notch1 plays a non-redundant role for thymic T cell development. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation and also found on bone marrow hematopoietic stem cells, NK cells, B cells, and monocytes .
Additional information: Clone REA849 displays negligible binding to Fc receptors.

Alternative Names

Notch 1, TAN-1, Motch A, mT14, p300, hN1

Technical specifications

  • Antigen: Notch1
  • Clone: REA849
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Notch 1, TAN-1, Motch A, mT14, p300, hN1
  • Entrez Gene ID: 18128
  • Molecular mass of antigen [kDa]: 269
  • Distribution of antigen: T cells, bone marrow, hematopoietic stem cells, NK cells, B cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBright 515, Biotin

Related products

2 products available
Product options: 8

Product information

Size
Order no.
Price

Anti-Notch1-PE, human

  • REA849
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-525
EUR 112,00 

Anti-Notch1-PE, human

  • REA849
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-453
EUR 296,00 

Anti-Notch1-APC, human

  • REA849
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-526
EUR 146,00 

Anti-Notch1-APC, human

  • REA849
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-454
EUR 322,00 

Anti-Notch1-VioBright 515, human

  • REA849
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-527
EUR 201,00 

Anti-Notch1-VioBright 515, human

  • REA849
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-455
EUR 402,00 

Anti-Notch1-Biotin, human

  • REA849
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-523
EUR 86,00 

Anti-Notch1-Biotin, human

  • REA849
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-451
EUR 252,00