Anti-Nanog antibodies, mouse

Anti-Nanog antibodies, mouse

Clone: REA297 | Dilution: 1:11
Clone REA297 recognizes the murine Nanog antigen, a homeobox transcription factor also known as ES cell-associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC) and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Overexpression of Nanog in mouse ESC causes them to self-renew in the absence of Leukemia inhibitory factor. Loss of Nanog function causes differentiation of mouse ESC into other cell types.
Additional information: Clone REA297 displays negligible binding to Fc receptors.

Alternative names

ENK, ecat4, Early embryo specific expression NK-type homeobox protein

Technical specifications

  • Antigen: Nanog
  • Clone: REA297
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ENK, ecat4, Early embryo specific expression NK-type homeobox protein
  • Entrez Gene ID: 71950
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: ES and iPS cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Mitsui et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: 631-642
    2. Lin, T. et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 7(2): 165-171
    3. Yates, A. et al. (2005) The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Biochem. Soc. Trans. 33(6): 1518-1521
Product options: 6
9 µg in 300 µL (1)
EUR 21,00 
30 µg in 1 mL (1)
EUR 41,00 
9 µg in 300 µL (1)
EUR 28,00 
30 µg in 1 mL (1)
EUR 82,00 
9 µg in 300 µL (1)
EUR 45,00 
30 µg in 1 mL (1)
EUR 82,00 

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