Anti-Myosin Heavy Chain antibodies, human, mouse, rat

Anti-Myosin Heavy Chain antibodies, human, mouse, rat

Clone: REA399 | Dilution: 1:10
Clone REA399 recognizes the human, mouse, and rat cardiac isoform of the myosin heavy chain (MHC) antigen. Myosin forms cross-bridges with actin in cardiac, smooth, and skeletal muscle, and cyclic cross-bridge activity is the basis for muscular contraction. It is a hexamer composed of two heavy chains, each of which contains an actin-binding site and an ATP hydrolysis site, and four light chains. Isoforms of each myosin subunit are expressed in cardiac, skeletal, and smooth muscle, and many are associated with distinct contractile properties in the muscles or single muscle fibers in which they are expressed. In cardiac muscle, two MHC isoforms, termed α-MHC and β-MHC, are present. α-MHC is associated with higher actomyosin ATPase activity compared with β-MHC. The relative amounts of the two isoforms may vary, with the ratio being a function of the hormonal status, the developmental stage, the animal, or the particular region of the heart.
Additional information: Clone REA399 displays negligible binding to Fc receptors.

Alternative names

MYH6, MYH7, MHC, MYHC

Technical specifications

  • Antigen: Myosin Heavy Chain
  • Clone: REA399
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MYH6, MYH7, MHC, MYHC
  • Entrez Gene ID: 4624, 4625
  • Molecular mass of antigen [kDa]: 223
  • Cross-reactivity: rabbit, cow, dog, pig
  • Distribution of antigen: smooth muscle, cardiac muscle, skeletal muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue, pure
Product options: 5
130-106-253

Anti-Myosin Heavy Chain-APC, human, mouse, rat

for 30
tests
(1)
EUR 110,00 
130-106-215

Anti-Myosin Heavy Chain-APC, human, mouse, rat

for 100
tests
(1)
EUR 265,00 
130-106-252

Anti-Myosin Heavy Chain-VioBlue, human, mouse, rat

for 30
tests
(1)
EUR 115,00 
130-106-214

Anti-Myosin Heavy Chain-VioBlue, human, mouse, rat

for 100
tests
(1)
EUR 275,00 
130-112-757

Anti-Myosin Heavy Chain pure, human, mouse, rat

100 µg in 100 µL
EUR 144,00