Anti-LT-ßR antibodies, human

Anti-LT-ßR antibodies, human

Clone: REA412 | Dilution: 1:11
Clone REA412 recognizes the human lymphotoxin beta receptor (LT-ßR) antigen, a 47 kDa single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (TNF-RIII). LT-ßR is a member of the TNF receptor family that play a role in the development and organization of lymphoid tissues. Unlike the other TNF receptors, LT-ßR does not bind a soluble ligand, but rather, a membrane form of a heterotrimeric lymphotoxin complex comprised of one LTα and two LTβ molecules. The development of lymph nodes is a process that involves the LT-ßR dependent crosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cells. Cell death induced by LT-ßR is dependent on TRAF3, whereas NFκB activation appears to be mediated by TRAF5 or TRAF2. LT-ßR is expressed on a variety of human primary and transformed cells, but is absent on T or B lymphocytes and primary monocytes or peripheral dendritic cells, although LT-ßR is detected on some myeloid leukemic lines. In the developing thymus LT-ßR is prominent along the trabeculae and into the medulla up to corticomedullary junction. In the spleen, LT-ßR is prominently expressed by cells in the red pulp and along the borders of red and white pulp which colocalizes with reticular stromal cells.
Additional information: Clone REA412 displays negligible binding to Fc receptors.

Alternative Names

TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR

Technical specifications

  • Antigen: LT-ßR
  • Clone: REA412
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR
  • Entrez Gene ID: 4055
  • Molecular mass of antigen [kDa]: 44
  • Distribution of antigen: myeloid leukemia cells, spleen, white pulp, red pulp, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770
Product options: 10

Product information

Size
Order no.
Price

Anti-LT-ßR-VioBright FITC, human

  • REA412
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-752
EUR 154,00 

Anti-LT-ßR-VioBright FITC, human

  • REA412
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-694
EUR 308,00 

Anti-LT-ßR-PE, human

  • REA412
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-748
EUR 112,00 

Anti-LT-ßR-PE, human

  • REA412
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-690
EUR 296,00 

Anti-LT-ßR-APC, human

  • REA412
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-749
EUR 146,00 

Anti-LT-ßR-APC, human

  • REA412
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-691
EUR 322,00 

Anti-LT-ßR-PE-Vio770, human

  • REA412
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-750
EUR 146,00 

Anti-LT-ßR-PE-Vio770, human

  • REA412
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-692
EUR 322,00 

Anti-LT-ßR-APC-Vio770, human

  • REA412
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-751
EUR 129,00 

Anti-LT-ßR-APC-Vio770, human

  • REA412
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-693
EUR 308,00 

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