Anti-IRF-4 antibodies, human and mouse

Anti-IRF-4 antibodies, human and mouse

Clone: REA201 | Dilution: 1:11
Clone REA201 recognizes IRF-4, which is a 52 KDa transcription factor and belongs to the family of interferon regulatory transcription factors (IRF).The IRF family consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain (DBD) with unique tryptophan pentad repeat and modulates the expression of genes regulated by the presence of interferons and in response to cell activation. Expression of IRF-4 is found in cells of the immune system, including lymphocytes, dendritic cells, and macrophages, where it's multiple functions include regulation of cell proliferation, apoptosis, and differentiation. Transcriptional activity of IRF-4 is further modulated by its interaction with various co-factors including including Pu.1, E47, STAT-6, and IRF-8.
Additional information: Clone REA201 displays negligible binding to Fc receptors.

Alternative names

IRF4, LSIRF, MUM1, NF-EM5, SHEP8, Spip, ICSAT14, LSIRF13

Technical specifications

  • Antigen: IRF-4
  • Clone: REA201
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF4, LSIRF, MUM1, NF-EM5, SHEP8, Spip, ICSAT14, LSIRF13
  • Entrez Gene ID: 3662
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: B cells, T cells, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Klein, U. et al. (2006) Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 7(7): 773-782
    2. Nayar, R. et al. (2012)
      TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8
      +
      T-cell differentiation.
      Proc. Natl. Acad. Sci. U.S.A. 109: E2794-E2802
    3. Biswas, P. S. et al. (2012) Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity. J. Exp. Med. 209: 581-596
Product options: 6
130-100-921

Anti-IRF-4-PE, human and mouse

for 30
tests
(1)
EUR 115,00 
130-100-917

Anti-IRF-4-PE, human and mouse

for 100
tests
(1)
EUR 270,00 
130-100-915

Anti-IRF-4-APC, human and mouse

for 30
tests
(1)
EUR 115,00 
130-100-913

Anti-IRF-4-APC, human and mouse

for 100
tests
(1)
EUR 270,00 
130-100-877

Anti-IRF-4-PE-Vio770, human and mouse

for 30
tests
(1)
EUR 120,00 
130-100-909

Anti-IRF-4-PE-Vio770, human and mouse

for 100
tests
(1)
EUR 290,00