Anti-Integrin β7 antibodies, human and mouse

Anti-Integrin β7 antibodies, human and mouse

Clone: REA441 | Dilution: 1:11
Clone REA441 recognizes the human and mouse integrin β7 antigen, a single-pass type I membrane protein which is also known as gut homing receptor β subunit. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin β7 subfamily has two known members (α4β7 and αEβ7) that are expressed primarily by leukocytes and have been implicated in secondary lymphoid structure formation, plasma cells homing to gastrointestinal mucosa, and inflammatory responses. Their ligands: the mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) and E-cadherin are present on the surface of endothelial cells, bone marrow stromal cells, and epithelial cells. Interaction of α4β7 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut, whereas αEβ7 retains intraepithelial lymphocytes within the gut epithelium through E-cadherin binding. Integrin β7 is also reported to be involved in the pathogenesis of several diseases such as colitis, diabetic insulitis, and lymphoid malignancies including lymphomatous polyposis in mantle cell lymphoma, thymic lymphoma, and mucosa-associated T cell and B cell non-Hodgkin lymphomas.
Additional information: Clone REA441 displays negligible binding to Fc receptors.

Alternative names

ITGB7, Ly69, M290 IEL

Technical specifications

  • Antigen: Integrin β7
  • Clone: REA441
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGB7, Ly69, M290 IEL
  • Entrez Gene ID: 16421
  • Molecular mass of antigen [kDa]: 86
  • Distribution of antigen: leukocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE-Vio770, Biotin
  • Selected references

    1. Alles, M. et al. (2014) Leukocyte β7 integrin targeted by Krüppel-like factors. J. Immunol. 193(4): 1737-1746
    2. Neri, P. et al. (2011) Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood 117(23): 6202-6213
    3. Hu, M. C. et al. (1992) Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc. Natl. Acad. Sci. U.S.A. 89(17): 8254-8258
Product options: 6
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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