Anti-IL-22 antibodies, mouse

Anti-IL-22 antibodies, mouse

Clone: REA721 | Dilution: 1:50
Clone REA721 recognizes the mouse interleukin 22 (IL-22) antigen, also known as IL-TIF. IL-22 is α-helical cytokine which is a member of the IL-10 cytokine family. It is produced by immune cells, including activated dendritic cells, T cells, and NK cells. The biological activity of IL-22 is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains. It initiates immune responses against bacterial pathogens especially in epithelial cells.
Additional information: Clone REA721 displays negligible binding to Fc receptors.

Alternative names

Interleukin-22, IL-TIF

Technical specifications

  • Antigen: IL-22
  • Clone: REA721
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Interleukin-22, IL-TIF
  • Entrez Gene ID: 50929
  • Molecular mass of antigen [kDa]: 17
  • Distribution of antigen: dendritic cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Domoutier, L. et al. (2000) Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. 164(4): 1814-1819
    2. Dumoutier, L. et al. (2000) IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun. 1(8): 488-494
    3. Wolk, K. et al. (2004) IL-22 increases the innate immunity of tissues. Immunity 21(2): 241-254
    4. Jones, B.C. et al. (2008) Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure 16(9): 1333-1344
Product options: 2
130-111-959

Anti-IL-22-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-111-806

Anti-IL-22-PE, mouse

150 µg in 1 mL (1)
EUR 230,00