Anti-IL-21 antibodies, human

Anti-IL-21 antibodies, human

Clone: 3A3-N2 | Dilution: 1:10
Interleukin 21 (IL-21) is secreted by a certain subset of CD4
+
T cells, called T follicular helper (Tfh) cells, also characterized by the expression of CXCR5 and ICOS and the lineage-specific transcription factor BCL6. But IL-21 production can also be found in other T helper (Tʜ) cell lineages and natural killer T (NKT) cells. IL-21 acts in a autocrine manner on Tfh cells and is critical for antibody production by B cells, it enhances natural killer (NK) cell functions, and promotes proliferation of CD8
+
T cells.

Alternative names

CVID11, Za11

Technical specifications

  • Antigen: IL-21
  • Clone: 3A3-N2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CVID11, Za11
  • Entrez Gene ID: 59067
  • Molecular mass of antigen [kDa]: 15
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE

  • Figure 1

    Human peripheral blood mononuclear cells (PBMCs) were incubated with or without (left images) PMA and ionomycin for 6 hours. After 2 hours, brefeldin A was added. The cells were harvested, fixed, permeabilized, and intracellularly stained with Anti-IL-21 antibodies and analyzed by flow cytometry using the MACSQuant
    ®
    Analyzer. Cell surface staining was performed with CD4 antibodies and CD154 antibodies. Gating was performed according to CD4 expression and side scatter properties of the cells. Cell debris was excluded from the analysis in a fluorescence 3 (FL-3/B2) versus fluorescence 4 (FL-4/B3) dot plot.
Product options: 2
130-096-868

Anti-IL-21-PE, human

for 100
tests
(1)
EUR 265,00 
130-099-946

Anti-IL-21-PE, human

for 30
tests
(1)
EUR 110,00 

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