Anti-IL-1β antibodies, human

Anti-IL-1β antibodies, human

Clone: REA1172 | Dilution: 1:50
Clone REA1172 recognizes the human IL-1β protein, a proinflammatory cytokine which belongs to the interleukin 1 (IL-1) family. IL-1β is primarly produced by macrophages, but also by monocytes and dendritic cells. It is secreted as a proprotein, that is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase/CASP1/ICE) to form mature IL-1β. It plays an essential role in inflammatory response, promotes cell differentiation, e.g. Tʜ17 differentiation of T cells, and is involved in other cellular activities, including apoptosis.
Additional information: Clone REA1172 displays negligible binding to Fc receptors.

Alternative names

IL-1beta, IL-1B, IL1B, IL1F2

Technical specifications

  • Antigen: IL-1β
  • Clone: REA1172
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IL-1beta, IL-1B, IL1B, IL1F2
  • Entrez Gene ID: 3553
  • Molecular mass of antigen [kDa]: 17
  • Cross-reactivity: baboon
  • Distribution of antigen: dendritic cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Vio515
  • Selected references

    1. Van Damme, J. et al. (1985) Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature 314(6008): 266-268
    2. Zsebo, K .M. et al. (1988) Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood 71(4): 962-968
    3. Lukens, J. R. et al. (2014) Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516(7530): 246-249
Product options: 6
130-120-955

Anti-IL-1β-PE, human

for 30
tests
(1)
EUR 110,00 
130-120-951

Anti-IL-1β-PE, human

for 100
tests
(1)
EUR 265,00 
130-120-956

Anti-IL-1β-APC, human

for 30
tests
(1)
EUR 110,00 
130-120-952

Anti-IL-1β-APC, human

for 100
tests
(1)
EUR 265,00 
130-120-957

Anti-IL-1β-Vio515, human

for 30
tests
(1)
EUR 115,00 
130-120-953

Anti-IL-1β-Vio515, human

for 100
tests
(1)
EUR 275,00 

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