Anti-IL-17F antibodies, human

Anti-IL-17F antibodies, human

Clone: LN2-9C4 | Dilution: 1:10
Clone LN2-9C4 recognizes the human interleukin 17F (IL-17F) antigen, a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17A, IL-17B, IL-17C, IL-17D, and IL-17E (also called IL-25). Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen’s cellular matrix. Phylogenetic analysis reveals that among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest homology to IL-17A (sharing 55 and 40% amino acid identity to IL-17A). IL-17F has been shown to have a pro-inflammatory role in asthma. It is expressed in the airway of asthmatics and its expression level is correlated with disease severity. IL-17F is able to induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. It is derived from several cell types such as T helper 17 cells, mast cells, and basophils, and shows a wide tissue expression pattern including lung. Overexpression of the IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.

Alternative Names

CANDF6, ML-1

Technical specifications

  • Antigen: IL-17F
  • Clone: LN2-9C4
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CANDF6, ML-1
  • Entrez Gene ID: 112744
  • Molecular mass of antigen [kDa]: 15
  • Distribution of antigen: T cells, mast cells, basophils, lung
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected References

    1. Starnes, T. et al. (2001) Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167(8): 4137-4140
    2. Yang, X. O. et al. (2008) Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205(5): 1063-1075
    3. Kawaguchi, M. et al. (2009) Role of interleukin-17F in asthma. Inflamm. Allergy Drug Targets 8(5): 383-389
Product options: 6
130-105-304

Anti-IL-17F-FITC, human

for 30
tests
(1)
EUR 90,00 
130-105-262

Anti-IL-17F-FITC, human

for 100
tests
(1)
EUR 220,00 
130-105-305

Anti-IL-17F-PE, human

for 30
tests
(1)
EUR 110,00 
130-105-263

Anti-IL-17F-PE, human

for 100
tests
(1)
EUR 265,00 
130-105-306

Anti-IL-17F-APC, human

for 30
tests
(1)
EUR 110,00 
130-105-264

Anti-IL-17F-APC, human

for 100
tests
(1)
EUR 265,00