Anti-IL-12 (p70) antibodies, human

Anti-IL-12 (p70) antibodies, human

Clone: REA123
Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages and by dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity. It induces the production of IFN-γ alone or in synergy with IL-2, acts as a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4
cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells. Clone REA123 reacts with the biologically active form of human IL-12 p70 heterodimer, but not with the p40 monomer or homodimer.
Additional information: Clone REA123 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: IL-12 (p70)
  • Clone: REA123
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IL12A, CLMF, NFSK, P35, IL12B, IMD28, IMD29, NKSF
  • Entrez Gene ID: 3592, 3593
  • Molecular mass of antigen [kDa]: 57
  • Distribution of antigen: monocytes, macrophages, dendritic cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Gubler, U. et al. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. U.S.A. 88(10): 4143-4147
    2. D´Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398
    3. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146
Product options: 1
100 µg in 100 µL
EUR 189,00