Anti-IFN-α antibodies, human

Anti-IFN-α antibodies, human

Clone: REA1013 | Dilution: 1:50
Clone REA1013 recognizes the human interferon alpha (IFN-α). Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of interleukin 12 (IL-12) and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123
+
CD11c
CD303 (BDCA2)
+
plasmacytoid dendritic cells (pDCs).
Additional information: Clone REA1013 displays negligible binding to Fc receptors.

Alternative Names

IFNA1

Technical specifications

  • Antigen: IFN-α
  • Clone: REA1013
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IFNA1
  • Entrez Gene ID: 3439, 3444, 3443, 3449, 3442, 3448, 3446, 3441, 3452, 3447, 3445, 3451, 3440
  • Molecular mass of antigen [kDa]: 20
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Vio667
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