Anti-IFN-α antibodies, human

Anti-IFN-α antibodies, human

Clone: LT27:295 | Dilution: 1:10
Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123
+
CD11c
-
CD303 (BDCA2)
+
plasmacytoid dendritic cells (pDCs). Clone LT27:295 recognizes the majority of the IFN-α subtypes, but not IFN-α2b.

Alternative names

IFNA1

Technical specifications

  • Antigen: IFN-α
  • Clone: LT27:295
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: IFNA1
  • Entrez Gene ID: 3439, 3440, 3451, 3445, 3447, 3452, 3441, 3446, 3448, 3442
  • Molecular mass of antigen [kDa]: 19-20
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, pure
  • Selected references

    1. Ronnblom, L. and Alm, G. V. (2001) An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 22: 427-431
    2. Båve, U. et al. (2003) FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171: 3296-3302
Product options: 7
130-099-233

Anti-IFN-α-FITC, human

for 30
tests
(1)
EUR 95,00 
130-092-600

Anti-IFN-α-FITC, human

for 100
tests
(1)
EUR 230,00 
130-099-098

Anti-IFN-α-PE, human

for 30
tests
(1)
EUR 115,00 
130-092-601

Anti-IFN-α-PE, human

for 100
tests
(1)
EUR 270,00 
130-099-214

Anti-IFN-α-APC, human

for 30
tests
(1)
EUR 115,00 
130-092-602

Anti-IFN-α-APC, human

for 100
tests
(1)
EUR 270,00 
130-092-604

Anti-IFN-α pure, human

100 µg in 1 mL
EUR 156,00