Anti-HLA-E antibodies, human

Anti-HLA-E antibodies, human

Clone: REA1031 | Dilution: 1:50
Clone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity.
Additional information: Clone REA1031 displays negligible binding to Fc receptors.

Alternative names

QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E

Technical specifications

  • Antigen: HLA-E
  • Clone: REA1031
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E
  • Entrez Gene ID: 3133
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Lu, L. et al. (2008)
      Generation and regulation of CD8
      +
      regulatory T cells.
      Cell. Mol. Immunol. 5(6): 401-406
    2. Jiang, H. et al. (2010)
      HLA-E-restricted regulatory CD8
      +
      T cells are involved in development and control of human autoimmune type 1 diabetes.
      J. Clin. Invest. 120(10): 3641-3650
    3. Pietra, G. et al. (2010)
      The emerging role of HLA-E-restricted CD8
      +
      T lymphocytes in the adaptive immune response to pathogens and tumors.
      J. Biomed. Biotechnol. : 907092
Product options: 10
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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