Anti-HLA-BC antibodies, human

Anti-HLA-BC antibodies, human

Clone: REA672 | Dilution: 1:50
Clone REA672 recognizes the class I human leukocyte antigens (HLA) B and C. Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA672 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: HLA-BC
  • Clone: REA672
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 3106, 3107
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Parham, P. et al. (1996) Population biology of antigen presentation by MHC class I molecules. Science 272(5258): 67-74
    2. Srivastava, R. et al. (1985) Molecular organization of the class I genes of human major histocompatibility complex. Immunol. Rev. 84: 93-121
Product options: 2
for 30
EUR 110,00 
for 100
EUR 265,00 

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