Anti-GARP (LRRC32) antibodies, human

Anti-GARP (LRRC32) antibodies, human

Clone: REA166 | Dilution: 1:11
Clone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β–binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells.
Additional information: Clone REA166 displays negligible binding to Fc receptors.

Alternative names

LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)

Technical specifications

  • Antigen: GARP (LRRC32)
  • Clone: REA166
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LRRC32, D11S833E, Glycoprotein A repetitions predominant (GARP)
  • Entrez Gene ID: 2615
  • Molecular mass of antigen [kDa]: 70
  • Distribution of antigen: platelets, other, T cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Zhou, A. X. et al. (2013)
      GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4
      +
      T cells
      in vivo
      .
      J. Immunol. 190(10): 5057-5064
    2. Tran, D. Q. et al. (2009)
      GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3
      +
      regulatory T cells.
      Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450
    3. Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219
Product options: 6
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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