Anti-Galectin-9 antibodies, human

Anti-Galectin-9 antibodies, human

Clone: REA435 | Dilution: 1:10
Clone REA435 recognizes the human galectin-9 antigen, a member of the galectin family of carbohydrate-binding proteins, which is also known as ecalectin or tumor antigen HOM-HD-21. The galectin family is characterized by the presence of two or more conserved carbohydrate-recognition domains that bind galactose. Galectin-9 is widely distributed throughout various tissues and circulates at very high levels in the serum. It interacts with various ligands, the best characterized of which is the T cell immunoglobulin mucin 3 (Tim-3) cell surface molecule, widely expressed on innate and adaptive immune cells. Originally described as an eosinophil chemoattractant, Galectin-9 is now known to be an important pleiotropic immune modulator affecting numerous immune cell types. Galectin-9 is thought to be involved in the activation of innate immune responses and the downregulation of Tʜ17 and Tʜ1 responses. It can promote inflammation through triggering proinflammatory cytokine production from monocytes and inducing maturation of macrophages and monocyte-derived dendritic cells. Conversely, Galectin-9 has a major anti-inflammatory role in the induction of apoptosis in activated T cell subsets, as well as in promoting the differentiation of regulatory T cells expressing FoxP3. Galectin-9 is also involved in the apoptosis of tumor cells.
Additional information: Clone REA435 displays negligible binding to Fc receptors.

Alternative Names

Lgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21

Technical specifications

  • Antigen: Galectin-9
  • Clone: REA435
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: Lgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21
  • Entrez Gene ID: 3965
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected References

    1. Golden-Mason, L. et al. (2013) Galectin-9 functionally impairs natural killer cells in humans and mice. J. Virol. 87(9): 4835-4845
    2. Matsumoto, R. et al. (1998) Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J. Biol. Chem. 273(27): 16976-16984
    3. Leitner, J. et al. (2013) TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 9(3): e1003253
Product options: 6

Product information

Size
Order no.
Price

Anti-Galectin-9-FITC, human

  • REA435
  • 1:10
  • For research use only
for 30
tests
(1)
130-106-521
EUR 65,00 

Anti-Galectin-9-FITC, human

  • REA435
  • 1:10
  • For research use only
for 100
tests
(1)
130-106-472
EUR 255,00 

Anti-Galectin-9-PE, human

  • REA435
  • 1:10
  • For research use only
for 30
tests
(1)
130-106-522
EUR 85,00 

Anti-Galectin-9-PE, human

  • REA435
  • 1:10
  • For research use only
for 100
tests
(1)
130-106-473
EUR 300,00 

Anti-Galectin-9-APC, human

  • REA435
  • 1:10
  • For research use only
for 30
tests
(1)
130-106-523
EUR 111,00 

Anti-Galectin-9-APC, human

  • REA435
  • 1:10
  • For research use only
for 100
tests
(1)
130-106-474
EUR 326,00