Anti-FoxA2 antibodies, human

Anti-FoxA2 antibodies, human

Clone: REA506 | Dilution: 1:11
Clone REA506 recognizes the human forkhead box A2 (FoxA2) antigen, a transcription factor which is also known as hepatocyte nuclear factor 3β (HNF-3β). FoxA2 is involved in embryonic development, establishment of tissue-specific gene expression, and regulation of gene expression in differentiated tissues. It is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. In embryonic development, FoxA2 is required for notochord formation. It is involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, and lungs. FoxA2 is also involved in glucose homeostasis. It regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis.
Additional information: Clone REA506 displays negligible binding to Fc receptors.

Alternative names

HNF3B, HNF-3B, TCF-3B, HNF-3β

Technical specifications

  • Antigen: FoxA2
  • Clone: REA506
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: HNF3B, HNF-3B, TCF-3B, HNF-3β
  • Entrez Gene ID: 3170
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: liver, lung, pancreas, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, pure
  • Selected references

    1. Li, Z. et al. (2012) Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell 151(7): 1608-1616
    2. Yi, S. H. et al. (2014) Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation. Development 141(4): 761-772
    3. Heddad Masson, M. et al. (2014) Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion. Endocrinology 155(10): 3781-3792
Product options: 3
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
100 µg in 1 mL
EUR 144,00 

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