Anti-EGF Receptor pY1068 antibodies, human

Anti-EGF Receptor pY1068 antibodies, human

Clone: REA644 | Dilution: 1:11
Clone REA644 recognizes the human epidermal growth factor receptor (EGFR) antigen phosphorylated at tyrosine 1068 (pY1068). EGFR is a single-pass type I membrane protein which is also known as receptor tyrosine-protein kinase ErbB-1 or HER1. It is a critical regulator of many normal cellular processes, including cell growth, differentiation, survival, and migration. The EGFR also is implicated in pathological processes of cellular transformation and oncogenesis due to its overexpression in many types of cancers and its ability to induce morphological transformation of cultured cells and tumor formation in nude mice. Many different signaling pathways have been discovered to mediate the effects of EGF, the most notable being Ras-mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase pathways. In these pathways EGF binds to the EGFR to induce dimerization, catalytic activation, and autophosphorylation of tyrosines in the C-terminal tail of the EGFR. These phosphorylated tyrosines provide docking sites for adapter proteins such as Grb2, Shc, and Gab2 to link the receptor to the Ras-MAPK, as well as phosphatidylinositol 3-kinase pathways.
Additional information: Clone REA644 displays negligible binding to Fc receptors.

Alternative names

erbB-1, HER1, ERBB, ERBB1, NISBD2, PIG61, mENA

Technical specifications

  • Antigen: EGF Receptor pY1068
  • Clone: REA644
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: erbB-1, HER1, ERBB, ERBB1, NISBD2, PIG61, mENA
  • Entrez Gene ID: 1956
  • Molecular mass of antigen [kDa]: 132
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Ullrich, A. et al. (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309(5967): 418-425
    2. Heisermann, G. J. et al. (1988)
      Epidermal growth factor receptor threonine and serine residues phosphorylated
      in vivo
      .
      J. Biol. Chem. 263(26): 13152-13158
Product options: 6
130-110-013

Anti-EGF Receptor pY1068-FITC, human

for 30
tests
(1)
EUR 95,00 
130-110-040

Anti-EGF Receptor pY1068-FITC, human

for 100
tests
(1)
EUR 230,00 
130-110-014

Anti-EGF Receptor pY1068-PE, human

for 30
tests
(1)
EUR 115,00 
130-110-041

Anti-EGF Receptor pY1068-PE, human

for 100
tests
(1)
EUR 270,00 
130-110-015

Anti-EGF Receptor pY1068-APC, human

for 30
tests
(1)
EUR 115,00 
130-110-042

Anti-EGF Receptor pY1068-APC, human

for 100
tests
(1)
EUR 270,00