Anti-DLL4 antibodies, mouse

Anti-DLL4 antibodies, mouse

Clone: REA1105 | Dilution: 1:50
Clone REA1105 recognizes the mouse DLL4, which is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, delta/serrate/LAG-2 (DSL) domain, and tandemly arranged multiple EGF–like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. As a ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling.
Additional information: Clone REA1105 displays negligible binding to Fc receptors.

Alternative names

Delta4

Technical specifications

  • Antigen: DLL4
  • Clone: REA1105
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Delta4
  • Entrez Gene ID: 54485
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Duarte, A. et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18: 2474-2478
    2. Krebs, L. T. et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469-2473
    3. D'Souza, B. et al. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol. 92: 73-129
Product options: 10
130-119-256

Anti-DLL4-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-119-082

Anti-DLL4-PE, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-119-257

Anti-DLL4-APC, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-119-083

Anti-DLL4-APC, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-119-258

Anti-DLL4-PE-Vio615, mouse

30 µg in 200 µL (1)
EUR 100,00 
130-119-084

Anti-DLL4-PE-Vio615, mouse

150 µg in 1 mL (1)
EUR 295,00 
130-119-259

Anti-DLL4-VioBright 515, mouse

30 µg in 200 µL (1)
EUR 145,00 
130-119-085

Anti-DLL4-VioBright 515, mouse

150 µg in 1 mL (1)
EUR 420,00 
130-119-260

Anti-DLL4-Biotin, mouse

30 µg in 200 µL (1)
EUR 40,00 
130-119-086

Anti-DLL4-Biotin, mouse

150 µg in 1 mL (1)
EUR 120,00