Anti-DLL4 antibodies, human

Anti-DLL4 antibodies, human

Clone: REA1065 | Dilution: 1:50
Clone REA1065 recognizes the human delta-like4 (DLL4) antigen, which is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.
Additional information: Clone REA1065 displays negligible binding to Fc receptors.

Alternative names

hdelta2, Delta-like4, Delta-like protein 4

Technical specifications

  • Antigen: DLL4
  • Clone: REA1065
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: hdelta2, Delta-like4, Delta-like protein 4
  • Entrez Gene ID: 54567
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32: 14-27
    2. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
    3. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
    4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205(11): 2507-2513
    5. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(11): 2515-2523
Product options: 22
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EUR 110,00 
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EUR 265,00 
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EUR 110,00 
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EUR 265,00 
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EUR 115,00 
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EUR 275,00 
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EUR 115,00 
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EUR 275,00 
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EUR 120,00 
for 100
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EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 150,00 
for 100
tests
(1)
EUR 360,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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