Anti-DLL4 antibodies, human

Anti-DLL4 antibodies, human

Clone: REA1065 | Dilution: 1:50
Clone REA1065 recognizes the human delta-like4 (DLL4) antigen, which is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling controls cell fate decisions and is involved in multiple developmental processes. Notch ligands are categorized into two subfamilies: the Jagged and the Delta ligand family. In mammals, five ligands (DLL 1, 3, and 4, Jagged 1 and 2) have been identified. DLL4 is highly expressed within vascular endothelial cells, thymic epithelial cells, and dendritic cell subsets and plays an important role for vascular development and homeostasis and thymic as well as peripheral T cell differentiation.
Additional information: Clone REA1065 displays negligible binding to Fc receptors.

Alternative Names

hdelta2, Delta-like4, Delta-like protein 4

Technical specifications

  • Antigen: DLL4
  • Clone: REA1065
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: hdelta2, Delta-like4, Delta-like protein 4
  • Entrez Gene ID: 54567
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: dendritic cells, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected References

    1. Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037
    2. Ridgeway, J. et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444(7122): 1083-1087
    3. Koch, U. et al. (2008) Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205(11): 2515-2523
    4. Hozumi, K. et al. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205(11): 2507-2513
    5. Radtke, F. et al. (2010) Notch signaling in the immune system. Immunity 32: 14-27
Product options: 22

Product information

Size
Order no.
Price

Anti-DLL4-FITC, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-378
EUR 90,00 

Anti-DLL4-FITC, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-224
EUR 220,00 

Anti-DLL4-PE, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-379
EUR 110,00 

Anti-DLL4-PE, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-225
EUR 265,00 

Anti-DLL4-APC, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-380
EUR 110,00 

Anti-DLL4-APC, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-226
EUR 265,00 

Anti-DLL4-VioBlue, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-381
EUR 115,00 

Anti-DLL4-VioBlue, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-227
EUR 275,00 

Anti-DLL4-VioGreen, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-382
EUR 115,00 

Anti-DLL4-VioGreen, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-228
EUR 275,00 

Anti-DLL4-PE-Vio615, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-383
EUR 120,00 

Anti-DLL4-PE-Vio615, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-229
EUR 290,00 

Anti-DLL4-PE-Vio770, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-384
EUR 120,00 

Anti-DLL4-PE-Vio770, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-230
EUR 290,00 

Anti-DLL4-APC-Vio770, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-385
EUR 120,00 

Anti-DLL4-APC-Vio770, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-231
EUR 290,00 

Anti-DLL4-PerCP-Vio700, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-386
EUR 120,00 

Anti-DLL4-PerCP-Vio700, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-232
EUR 290,00 

Anti-DLL4-VioBright 515, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-387
EUR 150,00 

Anti-DLL4-VioBright 515, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-233
EUR 360,00 

Anti-DLL4-Biotin, human

  • REA1065
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-388
EUR 90,00 

Anti-DLL4-Biotin, human

  • REA1065
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-234
EUR 220,00