Anti-CCL5 (RANTES) antibodies, human

Anti-CCL5 (RANTES) antibodies, human

Clone: REA346 | Dilution: 1:10
Clone REA346 recognizes the human C-C motif chemokine 5 (CCL5) antigen, a 8 kDa protein also known as RANTES (regulated on activation, normal T cell expressed and secreted). CCL5 belongs to the C-C chemokine family and is a target gene of NF-κB activity. It is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells. NF-κB activation by different stimuli such as CD40L or interleukin 15 (IL-15) induces CCL5 production. CCL5 plays an active role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and interferon γ (IFN-γ), CCL5 also induces the activation and proliferation of particular natural killer cells to generate C-C chemokine-activated killer cells. CCL5 produced by CD8
+
T cells and other immune cells has been shown to inhibit HIV entry into target cells. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5. CCR4 and CD44 are auxiliary receptors for CCL5.
Additional information: Clone REA346 displays negligible binding to Fc receptors.

Alternative names

C-C motif chemokine 5, SCYA5, SIS-delta, SISd, TCP228, EoCP, T-cell-specific protein RANTES, RANTES

Technical specifications

  • Antigen: CCL5 (RANTES)
  • Clone: REA346
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: C-C motif chemokine 5, SCYA5, SIS-delta, SISd, TCP228, EoCP, T-cell-specific protein RANTES, RANTES
  • Entrez Gene ID: 6352
  • Molecular mass of antigen [kDa]: 8
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: T cells, macrophages, platelets, fibroblasts, epithelial cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Schall, T. J. et al. (1988) A human T cell-specific molecule is a member of a new gene family J. Immunol. 141(3): 1018-1025
    2. Capoulade-Métay, C. et al. (2006) A natural CCL5/RANTES variant antagonist for CCR1 and CCR3. Immunogenetics 58(7): 533-541
    3. Long, H. et al. (2012)
      Autocrine CCL5 signaling promotes invasion and migration of CD133
      +
      ovarian cancer stem-like cells via NF-κB-mediated MMP-9 up regulation.
      Stem Cells 30(10): 2309-2319
Product options: 4
130-105-493

Anti-CCL5 (RANTES)-PE, human

for 30
tests
(1)
EUR 110,00 
130-105-450

Anti-CCL5 (RANTES)-PE, human

for 100
tests
(1)
EUR 265,00 
130-105-494

Anti-CCL5 (RANTES)-APC, human

for 30
tests
(1)
EUR 110,00 
130-105-451

Anti-CCL5 (RANTES)-APC, human

for 100
tests
(1)
EUR 265,00