Anti-CCL2 (MCP-1) antibodies, human

Anti-CCL2 (MCP-1) antibodies, human

Clone: REA248 | Dilution: 1:10
Clone REA248 recognizes the monocyte chemotactic protein 1 (MCP-1) antigen, a member of the beta (C-C) chemokine subfamily, which is also known as C-C motif chemokine 2 (CCL2) or monocyte chemotactic and activating factor (MCAF). MCP-1 is anchored in the plasma membrane of endothelial cells and is primarily secreted by monocytes, macrophages, and dendritic cells. Platelet-derived growth factor is a major inducer of the MCP-1 gene. MCP-1 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis, or atherosclerosis.
Additional information: Clone REA248 displays negligible binding to Fc receptors.

Alternative names

GDCF-2, HC11, HSMCR30, MCAF, MCP-1, Scya2, SMC-CF

Technical specifications

  • Antigen: CCL2 (MCP-1)
  • Clone: REA248
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: GDCF-2, HC11, HSMCR30, MCAF, MCP-1, Scya2, SMC-CF
  • Entrez Gene ID: 6347
  • Molecular mass of antigen [kDa]: 9
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: monocytes, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Yoshimura, T. and Leonard, E. J. (1991) Human monocyte chemoattractant protein-1 (MCP-1). Adv. Exp. Med. Biol. 305: 47-56
    2. Paavola, C. D. et al. (1998) Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. J. Biol. Chem. 273(50): 33157-33165
    3. Xia, M. and Sui, Z. (2009) Recent developments in CCR2 antagonists. Expert Opin. Ther. Pat. 19(3): 295-303
Product options: 4
130-101-674

Anti-CCL2 (MCP-1)-PE, human

for 30
tests
(1)
EUR 110,00 
130-101-750

Anti-CCL2 (MCP-1)-PE, human

for 100
tests
(1)
EUR 265,00 
130-101-672

Anti-CCL2 (MCP-1)-APC, human

for 30
tests
(1)
EUR 110,00 
130-101-752

Anti-CCL2 (MCP-1)-APC, human

for 100
tests
(1)
EUR 265,00