Anti-c-Cbl pY774 antibodies, human

Anti-c-Cbl pY774 antibodies, human

Clone: REA118 | Dilution: 1:11
Clone REA118 recognizes the Y774-phosphorylated form of human c-Cbl, which is a member of Cbl family of proteins. Cbl proteins serve as the negative regulators of antigen receptor signaling and contain N-terminal tyrosine kinase-binding (TKB) domain, which mediates binding to specific phosphotyrosine motifs on activated protein tyosine kinases (PTKs), a Zn-coordinating RING finger domain that interacts with ubiquitin-conjugating enzymes (E2s), a proline-rich region and a C-terminal leucine zipper-like region. c-Cbl unlike the other cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. Cbl proteins acts as E3 ubiquitin ligase and tranfer ubiquitin molecules to tag activated receptors, PTKS, and signaling molecules for degradation.
Additional information: Clone REA118 displays negligible binding to Fc receptors.

Alternative Names

CBL, CBL2, FRA11B, NSLL, RNF55

Technical specifications

  • Antigen: c-Cbl pY774
  • Clone: REA118
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CBL, CBL2, FRA11B, NSLL, RNF55
  • Entrez Gene ID: 867
  • Molecular mass of antigen [kDa]: 100
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected References

    1. Joazeiro, C. A. P. et al. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309
    2. Rao, N. et al. (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J. Leukoc. Biol. 71: 753-763
Product options: 8

Product information

Size
Order no.
Price

Anti-c-Cbl pY774-PE, human

  • REA118
  • 1:11
  • For research use only
for 30
tests
(1)
130-099-298
EUR 110,00 

Anti-c-Cbl pY774-PE, human

  • REA118
  • 1:11
  • For research use only
for 100
tests
(1)
130-099-294
EUR 265,00 

Anti-c-Cbl pY774-APC, human

  • REA118
  • 1:11
  • For research use only
for 30
tests
(1)
130-099-307
EUR 110,00 

Anti-c-Cbl pY774-APC, human

  • REA118
  • 1:11
  • For research use only
for 100
tests
(1)
130-099-302
EUR 265,00 

Anti-c-Cbl pY774-PE-Vio770, human

  • REA118
  • 1:11
  • For research use only
for 30
tests
(1)
130-099-315
EUR 120,00 

Anti-c-Cbl pY774-PE-Vio770, human

  • REA118
  • 1:11
  • For research use only
for 100
tests
(1)
130-099-311
EUR 290,00 

Anti-c-Cbl pY774-PerCP-Vio700, human

  • REA118
  • 1:11
  • For research use only
for 30
tests
(1)
130-099-318
EUR 120,00 

Anti-c-Cbl pY774-PerCP-Vio700, human

  • REA118
  • 1:11
  • For research use only
for 100
tests
(1)
130-099-317
EUR 290,00