Anti-BDNF antibodies, human

Anti-BDNF antibodies, human

Clone: REA358 | Dilution: 1:10
Clone REA358 recognizes the human brain-derived neurotrophic factor (BDNF) antigen, a secreted protein which is a member of the neurotrophin family of growth factors and related to the canonical nerve growth factor. BDNF is highly expressed in hippocampus, amygdala, cerebral cortex, and cerebellum. It is also expressed in heart, lung, skeletal muscle, testis, prostate, and placenta. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding, and in the modulation of dendritic growth and morphology. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Binding of BDNF to its receptor TrkB elicits various intracellular signaling pathways, including MAPK/ERK, PLCg, and PI3K pathways.
Additional information: Clone REA358 displays negligible binding to Fc receptors.

Alternative Names

ANON2, BULN2

Technical specifications

  • Antigen: BDNF
  • Clone: REA358
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ANON2, BULN2
  • Entrez Gene ID: 627
  • Molecular mass of antigen [kDa]: 13
  • Distribution of antigen: placenta, brain, heart, lung, skeletal muscle, testicle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected References

    1. Jones, K. R. et al. (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Natl. Acad. Sci. U.S.A. 87(20): 8060-8064
    2. Numakawa, T. et al. (2010) BDNF function and intracellular signaling in neurons. Histol. Histopathol. 25(2): 237-258
    3. Yoshii, A. et al. (2010) Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev. Neurobiol. 70(5): 304-322
Product options: 4

Product information

Size
Order no.
Price

Anti-BDNF-PE, human

  • REA358
  • 1:10
  • For research use only
for 30
tests
(1)
130-105-181
EUR 85,00 

Anti-BDNF-PE, human

  • REA358
  • 1:10
  • For research use only
for 100
tests
(1)
130-105-120
EUR 300,00 

Anti-BDNF-APC, human

  • REA358
  • 1:10
  • For research use only
for 30
tests
(1)
130-105-182
EUR 111,00 

Anti-BDNF-APC, human

  • REA358
  • 1:10
  • For research use only
for 100
tests
(1)
130-105-121
EUR 326,00