Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

The Cardiac Progenitor Cell Isolation Kit (Sca-1) has been specifically developed for the isolation of cardiac progenitor cells from mouse heart tissue.

Background information

A population of cardiac progenitor cells from the adult myocardium based on their expression of stem cell antigen-1 (Sca-1) has been identified.
1
These cells express most cardiogenic transcription factors but lack expression of cardiac structural genes. After treatment with 5-azacytidine, cardiac differentiation was induced in Sca-1
+
cells
in vitro
. In addition, this population homed to the injured myocardium upon grafting in an ischemia/reperfusion mouse model following by cardiac differentiation and fusion to the host myocardium. The majority of Sca-1
+
cells in the adult mouse heart co-express the endothelial marker CD31.
1,2
It has been shown that only the CD31
-
but not CD31
+
population exhibit functional cardiomyogenic differentiation.
2
In conclusion, Sca-1
+
/CD31
-
cells represent a distinct cardiac progenitor cell population, capable of differentiation into mature cardiomyocytes.

Columns

MS, LS, or autoMACS
®
Columns.
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Product information

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Order no.
Price

Cardiac Progenitor Cell Isolation Kit (Sca-1), mouse

  • For research use only
for
up to
100
separation
130-098-374
EUR 759,00